CLINICAL TRIALS AND OBSERVATIONS Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement
نویسندگان
چکیده
1Program in Pharmacogenetics, Department of Pharmacology, and 2Medical Scientist Program, School of Biomedical Science, College of Medicine, The Ohio State University, Columbus; 3Department of Pharmacy Practice, University of Illinois at Chicago; 4Department of Pharmacy Practice and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville; and 5Dorothy Davis Heart and Lung Research Institute and College of Pharmacy, The Ohio State University, Columbus
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CLINICAL TRIALS AND OBSERVATIONS The largest prospective warfarin-treated cohort supports genetic forecasting
Genetic variants of cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) are known to influence warfarin dose, but the effect of other genes has not been fully elucidated. We genotyped 183 polymorphisms in 29 candidate genes in 1496 Swedish patients starting warfarin treatment, and tested for association with response. CYP2C9*2 and *3 explained 12% (P 6.63 10 34) of the variati...
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